The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment
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The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment
Rodent malaria species Plasmodium yoelii and P. chabaudi have been widely used to validate vaccine approaches targeting blood-stage merozoite antigens. However, increasing data suggest the P. berghei rodent malaria may be able to circumvent vaccine-induced anti-merozoite responses. Here we confirm a failure to protect against P. berghei, despite successful antibody induction against leading mer...
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Background and Aims: The aim of this study is to clarify nitric oxide (NO)-production by spleen and the importance of spleen in malaria infection in murine model. Materials and Methods: Thirty outbred NMRI female mice were divided into four groups, Group I: No intervention (Healthy control), Group II: With splenectomy (Healthy test), Group III: No intervention, Inoculation of contaminated bloo...
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چکیده ندارد.
15 صفحه اولTransgenic rodent Plasmodium berghei parasites as tools for assessment of functional immunogenicity and optimization of human malaria vaccines.
Functional assessments of immune responses against stagespecific antigens of Plasmodium falciparum, the agent of the deadliest form of human malaria, are limited mainly to in vitro assays because P. falciparum cannot infect small animals, such as rodents. Hence, antibodies from individuals who have been naturally infected or vaccinated against malaria during clinical trials have been evaluated ...
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b ackground: animal models with various combination of host-parasite have long been employed to study malaria pathogenesis. here, we describe the combination of plasmodium berghei anka infec- tion in inbred icr mice as a model of cerebral malaria (cm). m ethods: infection in mice was initiated by intraperitoneal injection of 2 x 107 (0.2ml) parasitized red blood cells (prbcs). r esults: this m...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2013
ISSN: 2045-2322
DOI: 10.1038/srep01706